If you are like me and your ISP blocks SMTP outbounnd traffic then you need to configure your mail client to use an SMTP relay to get around this problem. Here are the steps.
vi /etc/postfix/main.cf
do a search for relayhost = and change it to your SMTP server of your ISP see my example below.
relayhost = smtp.west.cox.net
/etc/init.d/postfix restart